Regulation of long-chain fatty acid import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of long-chain fatty acid import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2_S560, IRS2_S594, and IRS2_S679, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-chain fatty acid import across plasma membrane activity versus IRS2_S560 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRS2_S560 →	+0.640	+0.045	<.001	<.001	3	8
COAD	IRS2_S594 →	+0.836	+0.057	<.001	<.001	3	7
CCRCC	IRS2_S679 →	+0.869	+0.051	<.001	<.001	3	7
BRCA	IRS2_S577 →	+0.890	+0.062	.001	.004	3	7
CCRCC	IRS2_S1100 →	+0.986	+0.051	<.001	<.001	3	6
BRCA	IRS2_S608 →	+0.758	+0.071	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010746 vs IRS2_S560 — CCRCC

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