Regulation of long-chain fatty acid import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of long-chain fatty acid import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, CCDC136, and CDC16, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-chain fatty acid import across plasma membrane activity versus IRS2 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS2 →	+1.676	+0.968	<.001	<.001	3	9
HNSC	CCDC136 →	+0.721	+0.633	.001	<.001	3	5
LSCC	CDC16 →	+0.441	+0.389	<.001	.004	3	5
CCRCC	KCNIP3 →	+0.912	+0.727	.002	.003	3	4
LSCC	LOXL3 →	+0.265	+0.448	.003	.001	3	4
HNSC	CARS2 →	+0.478	+0.571	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010746 vs IRS2 — UCEC

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