Negative regulation of macrophage derived foam cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage derived foam cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP4_S696, CNOT3_S299, and NCL_S67, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage derived foam cell differentiation activity versus MAP4_S696 in COAD (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAP4_S696 →	-0.465	-0.041	<.001	<.001	3	7
COAD	CNOT3_S299 →	-0.437	-0.046	.002	<.001	3	6
GBM	NCL_S67 →	-0.795	-0.101	<.001	<.001	3	6
OV	SRRM2_S1694 →	-1.010	-0.052	<.001	.009	3	6
OV	SRRM2_S1132 →	-0.718	-0.058	<.001	.001	3	6
GBM	GTF3C3 →	-0.288	-0.088	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010745 vs MAP4_S696 — COAD

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