Negative regulation of macrophage derived foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNC2, PRR15L, and ST3GAL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BNC2 grouped by Negative regulation of macrophage derived foam cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BNC2 →	+2.681	+1.668	<.001	<.001	3	6
LUNG_SCLC	PRR15L →	-3.376	-1.173	.007	.004	3	5
LUNG_NSCLC_LUAD	ST3GAL2 →	+1.309	+0.682	<.001	.001	3	5
PANCREAS	DSC2 →	-2.666	-0.973	<.001	.009	3	5
OESOPHAGUS	INPP1 →	+1.182	+1.111	.002	.007	3	5
SOFT_TISSUE	DOCK2 →	+1.651	+1.004	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BNC2 by Negative regulation of macrophage derived foam cell differentiation activity — BONE

Explore this box plot interactively →