Positive regulation of macrophage derived foam cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRB2, VSIG4, and HCK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage derived foam cell differentiation activity versus ARRB2 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARRB2 →	+0.646	+0.269	<.001	.002	3	6
LSCC	VSIG4 →	+0.560	+0.238	.004	.001	3	6
GBM	HCK →	+0.742	+0.213	.004	.006	3	5
GBM	TNFRSF1B →	+0.889	+0.267	.001	<.001	3	5
OV	CLEC1A →	+0.437	+0.201	.002	<.001	3	5
OV	ASGR2 →	+0.419	+0.199	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010744 vs ARRB2 — GBM

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