Positive regulation of macrophage derived foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGFG2, NIPSNAP1, and CCDC90B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGFG2 grouped by Positive regulation of macrophage derived foam cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AGFG2 →	-1.408	-1.269	<.001	<.001	3	4
LARGE_INTESTINE	NIPSNAP1 →	+1.144	+0.982	<.001	.002	3	4
CNS	CCDC90B →	-0.541	-1.073	.002	<.001	3	4
LARGE_INTESTINE	ATP5F1E →	-1.107	-0.621	<.001	.007	3	4
LARGE_INTESTINE	PLEKHH1 →	+1.661	+0.977	.004	.001	3	4
PANCREAS	SPHK1 →	+1.724	+1.138	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGFG2 by Positive regulation of macrophage derived foam cell differentiation activity — OVARY

Explore this box plot interactively →