Positive regulation of macrophage derived foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFKB1, KLC4, and ATAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage derived foam cell differentiation activity versus NFKB1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NFKB1 →	+0.961	+0.236	<.001	<.001	3	9
LARGE_INTESTINE	KLC4 →	-0.762	-0.137	.003	<.001	3	7
OVARY	ATAT1 →	-0.795	-0.125	.002	.007	3	6
LARGE_INTESTINE	ZC3H12C →	+0.769	+0.093	<.001	.005	3	6
LUNG_NSCLC_LUSC	PAN2 →	-1.118	-0.185	<.001	.004	3	6
SOFT_TISSUE	SEMA6C →	-1.759	-0.181	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010744 vs NFKB1 — UPPER_AERODIGESTIVE_TRACT

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