Regulation of macrophage derived foam cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, ARRB2, and LILRB4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage derived foam cell differentiation activity versus RASAL3 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RASAL3 →	+0.616	+0.354	.002	<.001	3	7
COAD	ARRB2 →	+0.431	+0.148	.001	.001	3	7
GBM	LILRB4 →	+0.679	+0.209	<.001	<.001	3	7
LSCC	CSF2RB →	+0.706	+0.264	.003	.004	3	6
OV	ACP2 →	+0.589	+0.162	<.001	.001	3	6
GBM	ZMYND15 →	+0.358	+0.225	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010743 vs RASAL3 — GBM

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