Regulation of macrophage derived foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR15L, MGST2, and CCNE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRR15L grouped by Regulation of macrophage derived foam cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRR15L →	-3.873	-1.193	.001	.004	3	5
PANCREAS	MGST2 →	-2.016	-0.907	.002	.003	3	4
LUNG_SCLC	CCNE2 →	-1.255	-0.903	.004	.003	3	4
BLOOD_Leukemia	BCORL1 →	+0.840	+0.664	.002	.006	3	4
BREAST	SMIM22 →	-3.523	-0.939	<.001	.001	3	4
LUNG_NSCLC_LUAD	QKI →	+0.804	+0.737	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRR15L by Regulation of macrophage derived foam cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →