Regulation of macrophage derived foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage derived foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, DAZAP1, and NFKBIE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage derived foam cell differentiation activity versus ITGAV in BREAST (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGAV →	+1.348	+1.103	<.001	<.001	3	5
URINARY_TRACT	DAZAP1 →	-0.674	-1.483	<.001	<.001	3	5
BLOOD_Leukemia	NFKBIE →	+1.070	+1.114	<.001	<.001	3	4
BLOOD_Leukemia	JUN →	-1.291	-0.750	.002	.007	3	4
BREAST	UXS1 →	+0.871	+0.810	<.001	.007	3	4
PANCREAS	RALB →	+1.265	+0.253	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010743 vs ITGAV — BREAST

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