Negative regulation of hydrogen peroxide metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of hydrogen peroxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FYN, HDAC6, and MPV17L, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hydrogen peroxide metabolic process activity versus FYN in SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	FYN →	+2.217	+0.296	<.001	<.001	3	19
DLBC	HDAC6 →	+0.592	+0.084	<.001	<.001	3	17
BRCA	MPV17L →	+1.113	+0.060	<.001	<.001	3	13
TGCT	STARD9 →	+1.008	+0.108	<.001	<.001	3	13
DLBC	SLX4 →	+0.954	+0.090	<.001	.002	2	14
DLBC	SEPSECS →	+0.659	+0.090	.002	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010727 vs FYN — SCLC

Explore this scatter interactively →