Negative regulation of hydrogen peroxide metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of hydrogen peroxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBSN, MAP1LC3A, and SLC25A24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hydrogen peroxide metabolic process activity versus RBSN in GBM (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBSN →	-0.172	-0.058	<.001	<.001	3	5
PDAC	MAP1LC3A →	-0.438	-0.051	.002	.007	3	5
GBM	SLC25A24 →	+0.575	+0.077	<.001	<.001	3	4
LSCC	XPO5 →	-0.472	-0.084	.002	.001	3	4
GBM	CSDC2_S47 →	-0.589	-0.046	.003	.001	3	4
LUAD	FHOD1_S523 →	+0.524	+0.062	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010727 vs RBSN — GBM

Explore this scatter interactively →