Negative regulation of cell development

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRG, BIRC7, and RSPH6A, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell development activity versus HRG in BRCA (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HRG →	+0.026	+0.605	.001	.003	3	2
COAD	BIRC7 →	+0.445	+0.423	<.001	<.001	3	1
COAD	RSPH6A →	-0.017	-0.425	.005	.006	3	1
COAD	DNAH7 →	-0.152	-0.299	.004	.003	3	1
COAD	IGFLR1 →	+0.291	+0.403	.007	<.001	3	1
COAD	IGLL1 →	+0.145	+0.291	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010721 vs HRG — BRCA

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