Regulation of epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CISH, MISP3, and NBEAL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CISH grouped by Regulation of epithelial to mesenchymal transition-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CISH →	+1.719	+0.169	.006	.003	3	5
LARGE_INTESTINE	MISP3 →	+1.035	+0.162	.003	<.001	3	5
PANCREAS	NBEAL2 →	+1.681	+0.240	<.001	.002	3	5
URINARY_TRACT	ISG15 →	+2.983	+0.415	.001	.006	3	4
LARGE_INTESTINE	DUSP16 →	+1.336	+0.198	.008	.008	3	4
LARGE_INTESTINE	PRR15L →	+2.257	+0.197	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CISH by Regulation of epithelial to mesenchymal transition activity — BREAST

Explore this box plot interactively →