Negative regulation of extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP1, PMP22, and TNFSF12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extracellular matrix disassembly activity versus TIMP1 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TIMP1 →	+1.917	+0.266	<.001	<.001	3	9
COAD	PMP22 →	+0.716	+0.265	.001	<.001	3	8
BRCA	TNFSF12 →	+0.776	+0.236	<.001	<.001	3	8
COAD	VIM →	+0.824	+0.278	.001	<.001	3	8
BRCA	FAM20A →	+0.952	+0.291	<.001	<.001	3	8
GBM	GBGT1 →	+0.604	+0.176	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010716 vs TIMP1 — GBM

Explore this scatter interactively →