Negative regulation of extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of extracellular matrix disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CST3_S43, DPP4, and NRP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extracellular matrix disassembly activity versus CST3_S43 in PDAC (Pearson r = 0.87).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CST3_S43 →	+0.760	+0.197	<.001	<.001	3	8
GBM	DPP4 →	+1.554	+0.362	<.001	<.001	3	7
OV	NRP1 →	+0.470	+0.174	.002	<.001	2	8
BRCA	RSU1 →	+0.314	+0.145	<.001	<.001	3	6
BRCA	SRPX2 →	+1.026	+0.264	<.001	<.001	3	6
BRCA	VIM_S22 →	+0.622	+0.172	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010716 vs CST3_S43 — PDAC

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