Positive regulation of collagen metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIPC, USF2, and AKAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIPC grouped by Positive regulation of collagen metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CIPC →	+0.606	+1.037	.007	.001	3	5
LUNG_SCLC	USF2 →	+0.865	+0.861	<.001	.005	3	5
LARGE_INTESTINE	AKAP3 →	+1.112	+1.024	.005	.006	3	5
LARGE_INTESTINE	SYNE2 →	+0.852	+0.937	<.001	<.001	3	5
BLOOD_Leukemia	MED29 →	+0.585	+0.869	<.001	.005	3	5
LUNG_SCLC	PKNOX1 →	+0.752	+0.623	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIPC by Positive regulation of collagen metabolic process activity — PANCREAS

Explore this box plot interactively →