Negative regulation of collagen metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYHIP, F2R, and NALCN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of collagen metabolic process activity versus PHYHIP in PDAC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PHYHIP →	+0.500	+0.145	<.001	.001	3	5
PDAC	F2R →	+0.482	+0.150	<.001	<.001	3	5
PDAC	NALCN →	+0.515	+0.153	.005	.001	3	4
PDAC	ZNF728 →	+0.552	+0.172	<.001	<.001	3	4
CCRCC	IGFBP7 →	+0.411	+0.131	.006	.001	2	5
HNSC	RN7SL336P →	+0.657	+0.088	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010713 vs PHYHIP — PDAC

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