Regulation of collagen metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS3, TNIP1, and LAMTOR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS3 grouped by Regulation of collagen metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RGS3 →	-1.911	-1.121	.003	.002	3	5
LUNG_NSCLC_LUSC	TNIP1 →	-1.511	-1.047	.006	.004	3	4
LUNG_NSCLC_LUSC	LAMTOR1 →	-0.998	-1.389	.008	<.001	3	4
LUNG_NSCLC_LUSC	AXL →	-4.416	-0.984	.001	.001	3	4
SKIN	S100A5 →	-0.629	-0.847	.003	.002	3	4
LIVER	AFF1 →	+0.818	+1.039	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS3 by Regulation of collagen metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →