Negative regulation of norepinephrine secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of norepinephrine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASSF4, TBX2_S676, and ADRA2A_S346, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of norepinephrine secretion activity versus RASSF4 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASSF4 →	-0.438	-0.230	<.001	.005	3	5
CCRCC	TBX2_S676 →	+0.610	+0.124	.001	<.001	3	4
OV	ADRA2A_S346 →	+1.168	+0.059	<.001	.008	3	4
PDAC	CEP68 →	+0.244	+0.067	.002	.004	3	4
PDAC	KCTD14 →	+0.503	+0.062	.004	.008	3	4
CCRCC	CDV3 →	-0.298	-0.100	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010700 vs RASSF4 — LSCC

Explore this scatter interactively →