Negative regulation of norepinephrine secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of norepinephrine secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF521, UCP2, and GRB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of norepinephrine secretion activity versus ZNF521 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF521 →	+1.070	+0.437	.004	.008	3	4
LUAD	UCP2 →	-1.255	-0.459	.001	<.001	3	3
LUAD	GRB2 →	-0.604	-0.417	.001	<.001	3	3
LUAD	RPS23P2 →	-0.216	-0.452	.001	<.001	3	3
PDAC	MSNP1 →	-0.354	-0.447	.001	.005	3	3
LSCC	PSMD12 →	-0.356	-0.293	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010700 vs ZNF521 — OV

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