Ectodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Ectodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A8, S100A12, and ADGRG3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectodermal cell differentiation activity versus S100A8 in LSCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	S100A8 →	+1.743	+0.106	.002	.005	3	6
UCEC	S100A12 →	+1.118	+0.257	<.001	<.001	3	5
UCEC	ADGRG3 →	+0.795	+0.182	<.001	.001	3	5
PDAC	PTAFR →	+0.432	+0.115	.008	.002	3	5
LUAD	UBFD1 →	-0.255	-0.137	.008	.003	3	4
LUAD	SNX25 →	-0.695	-0.165	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010668 vs S100A8 — LSCC

Explore this scatter interactively →