Ectodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Ectodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41, PPT2, and FAM81A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPB41 grouped by Ectodermal cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPB41 →	+1.545	+1.171	.006	.006	3	4
BLOOD_Leukemia	PPT2 →	+1.634	+1.204	.003	.008	3	4
SOFT_TISSUE	FAM81A →	+3.030	+1.632	.002	<.001	3	4
OESOPHAGUS	CYB5R4 →	+0.864	+1.432	<.001	<.001	3	4
BREAST	ARHGAP39 →	-0.897	-0.774	.003	.001	3	4
BLOOD_Myeloma	SLC9A3 →	-0.683	-1.998	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPB41 by Ectodermal cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →