Negative regulation of striated muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of striated muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL26, GAL3ST1, and TEDC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle cell apoptotic process activity versus KLHL26 in HNSC (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLHL26 →	+0.554	+0.184	<.001	.002	3	4
CCRCC	GAL3ST1 →	+0.725	+0.393	.002	.004	3	3
CCRCC	TEDC2 →	+0.259	+0.322	.002	.003	3	3
CCRCC	TMEM169 →	+0.533	+0.326	.001	.004	3	3
CCRCC	FEN1 →	+0.337	+0.396	<.001	<.001	3	3
CCRCC	C11orf45 →	+0.328	+0.251	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010664 vs KLHL26 — HNSC

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