Negative regulation of striated muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM16L, CGAS, and TCEAL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM16L grouped by Negative regulation of striated muscle cell apoptotic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRIM16L →	+2.044	+0.292	.002	<.001	3	5
SOFT_TISSUE	CGAS →	+1.951	+0.298	.003	<.001	3	5
LARGE_INTESTINE	TCEAL3 →	+1.271	+0.206	.001	<.001	3	5
SOFT_TISSUE	RPL3 →	-0.625	-0.296	.002	.001	3	4
OVARY	RELB →	+0.804	+0.209	.007	.008	3	4
LUNG_NSCLC_LUAD	RARRES1 →	+1.871	+0.202	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM16L by Negative regulation of striated muscle cell apoptotic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →