Muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD93, MAMDC2, and CD34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell apoptotic process activity versus CD93 in LSCC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD93 →	-0.531	-0.140	.001	.007	3	4
LUAD	MAMDC2 →	-1.292	-0.171	<.001	<.001	3	4
PDAC	CD34 →	-0.387	-0.161	.001	.001	3	4
BRCA	RHOJ →	-0.458	-0.127	.004	.002	3	4
BRCA	ZNF583 →	-0.351	-0.161	.002	.001	3	4
BRCA	MAMDC2-AS1 →	-0.126	-0.134	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010657 vs CD93 — LSCC

Explore this scatter interactively →