Muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SECISBP2L, ABCD3, and INPP5K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell apoptotic process activity versus SECISBP2L in STOMACH (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SECISBP2L →	-1.061	-0.148	.005	.002	3	4
BLOOD_Myeloma	ABCD3 →	+0.710	+0.443	.003	.006	3	3
BLOOD_Myeloma	INPP5K →	-0.534	-0.294	.006	.004	3	3
BLOOD_Myeloma	MYL6B →	+0.851	+0.310	<.001	.001	3	3
LARGE_INTESTINE	GLUD1 →	-0.608	-0.208	<.001	.001	3	3
LARGE_INTESTINE	DNAJB14 →	-0.715	-0.174	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010657 vs SECISBP2L — STOMACH

Explore this scatter interactively →