Negative regulation of muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAT2A, AKR1C2, and C1QC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle cell apoptotic process activity versus MAT2A in UCEC (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAT2A →	-0.119	-0.041	.006	<.001	3	5
LSCC	AKR1C2 →	+1.194	+0.032	<.001	<.001	3	5
COAD	C1QC →	+0.559	+0.039	.002	<.001	3	5
LSCC	GCLM →	+0.605	+0.039	.003	<.001	3	5
COAD	GCC2 →	-0.187	-0.027	.002	<.001	3	5
OV	SFRP2 →	+1.721	+0.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010656 vs MAT2A — UCEC

Explore this scatter interactively →