Negative regulation of muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, E2F7, and NDC80, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle cell apoptotic process activity versus MCM4 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM4 →	+0.808	+0.194	<.001	<.001	3	6
UCEC	E2F7 →	+0.585	+0.252	.005	.007	3	6
UCEC	NDC80 →	+0.823	+0.329	.002	.009	3	6
LUAD	CDC20 →	+1.121	+0.118	<.001	.006	3	5
HNSC	TUBG1 →	+0.752	+0.165	<.001	<.001	3	5
LUAD	CDC6 →	+0.890	+0.151	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010656 vs MCM4 — LSCC

Explore this scatter interactively →