Negative regulation of muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNF, SKA1, and ELAVL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle cell apoptotic process activity versus CCNF in LIVER (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCNF →	+0.925	+0.248	<.001	<.001	3	8
BLOOD_Leukemia	SKA1 →	+0.698	+0.243	.001	<.001	3	8
PANCREAS	ELAVL1 →	+0.855	+0.451	.002	<.001	3	7
OVARY	ILF3 →	+0.651	+0.274	<.001	<.001	3	7
LUNG_SCLC	RPS2 →	+1.013	+0.226	<.001	<.001	3	7
OVARY	NOB1 →	+0.950	+0.255	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010656 vs CCNF — LIVER

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