Regulation of cell communication by electrical coupling

Across TCGA patient cohorts, RNA activity of the Regulation of cell communication by electrical coupling pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMK2D, STRBP, and KIF15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling activity versus CAMK2D in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CAMK2D →	+0.374	+0.055	<.001	.001	3	7
LSCC	STRBP →	-0.429	-0.054	<.001	<.001	3	5
GBM	KIF15 →	-0.497	-0.076	.001	.004	3	5
LSCC	CHEK2 →	-0.491	-0.089	<.001	<.001	3	5
LSCC	GIGYF1_S137 →	+0.526	+0.046	<.001	.001	3	5
PDAC	CAST →	+0.199	+0.043	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010649 vs CAMK2D — LUAD

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