Regulation of cell communication by electrical coupling

Across TCGA patient cohorts, RNA activity of the Regulation of cell communication by electrical coupling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, FAM189A2, and PDE1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling activity versus ANK3 in OV (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANK3 →	+1.001	+0.838	<.001	<.001	3	6
UCEC	FAM189A2 →	+1.308	+0.696	<.001	<.001	3	6
GBM	PDE1A →	+0.787	+0.434	.001	.003	3	5
GBM	VIPR1 →	+0.439	+0.528	.001	<.001	3	5
CCRCC	NDUFAF4P3 →	+0.493	+0.811	<.001	.001	3	5
CCRCC	CASP12 →	+0.628	+0.824	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010649 vs ANK3 — OV

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