Regulation of cell communication by electrical coupling

Across TCGA cell cohorts, RNA activity of the Regulation of cell communication by electrical coupling pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, SHOC2, and BMP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYBL2 grouped by Regulation of cell communication by electrical coupling-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MYBL2 →	-0.725	-0.205	.004	.001	3	6
LUNG_SCLC	SHOC2 →	+0.149	+0.142	.005	.007	3	5
LUNG_SCLC	BMP2 →	-0.176	-0.212	.002	.003	3	5
PANCREAS	BIRC7 →	-0.146	-0.195	.003	.001	3	5
PANCREAS	ANPEP →	-0.116	-0.138	.005	.001	3	5
BLOOD_Leukemia	CEBPA →	-0.322	-0.111	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYBL2 by Regulation of cell communication by electrical coupling activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →