Regulation of cell communication by electrical coupling

Across TCGA cell cohorts, RNA activity of the Regulation of cell communication by electrical coupling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOV, RHOC, and P4HA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling activity versus RHOV in LIVER (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RHOV →	-1.060	-0.386	<.001	<.001	3	6
BONE	RHOC →	+2.355	+0.438	.001	.008	3	6
BONE	P4HA2 →	+3.235	+0.328	.002	.003	2	7
CNS	P3H1 →	+1.326	+0.392	<.001	<.001	3	6
CNS	CD163L1 →	+2.139	+0.329	<.001	<.001	3	6
LUNG_SCLC	IRF9 →	+1.747	+0.305	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010649 vs RHOV — LIVER

Explore this scatter interactively →