Cell communication by electrical coupling

Across TCGA cell cohorts, RNA activity of the Cell communication by electrical coupling pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3TC2, DYSF, and TGFBI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3TC2 grouped by Cell communication by electrical coupling-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3TC2 →	-1.632	-0.742	<.001	.001	3	5
PANCREAS	DYSF →	-2.702	-1.316	.002	.001	3	4
STOMACH	TGFBI →	-3.712	-0.981	.002	.001	3	4
SKIN	CYB561D1 →	-0.488	-0.867	<.001	.001	2	4
BREAST	POLI →	+0.718	+0.466	.001	.004	3	3
BREAST	MBNL2 →	-1.262	-0.687	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3TC2 by Cell communication by electrical coupling activity — LARGE_INTESTINE

Explore this box plot interactively →