Positive regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1R, HIP1, and BCAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of platelet-derived growth factor receptor signaling pathway activity versus HIP1R in OV (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HIP1R →	+0.449	+0.075	<.001	<.001	3	6
LSCC	HIP1 →	+0.291	+0.098	<.001	<.001	3	6
LUAD	BCAT1 →	+0.500	+0.047	.001	.006	3	5
BRCA	PLXDC2 →	+0.451	+0.063	.001	.001	3	5
LUAD	S100B →	+0.565	+0.041	.004	.008	3	4
LUAD	TJP3_S203 →	+0.608	+0.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010641 vs HIP1R — OV

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