Positive regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, CHRM3-AS1, and CRYBG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of platelet-derived growth factor receptor signaling pathway activity versus F3 in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	F3 →	+1.596	+0.328	<.001	<.001	3	4
UCEC	CHRM3-AS1 →	-0.853	-0.177	.005	.001	3	4
LSCC	CRYBG1 →	+0.552	+0.122	.001	.006	3	3
HNSC	DIPK2A →	-0.907	-0.196	.003	.002	3	3
LSCC	TSPEAR-AS2 →	-0.582	-0.121	.005	<.001	3	3
LSCC	CASP4 →	+0.358	+0.133	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010641 vs F3 — UCEC

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