Positive regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMF2, MCCC2, and ARFGAP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMF2 grouped by Positive regulation of platelet-derived growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LMF2 →	-0.740	-1.028	<.001	<.001	3	6
LUNG_SCLC	MCCC2 →	+1.399	+1.554	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ARFGAP3 →	-1.216	-2.307	.001	<.001	3	5
LUNG_NSCLC_LUSC	NLRP1 →	-2.766	-1.592	<.001	.001	3	5
LUNG_SCLC	ZNF441 →	-1.595	-1.316	.001	.002	3	4
LUNG_SCLC	ZNF564 →	-0.614	-1.265	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMF2 by Positive regulation of platelet-derived growth factor receptor signaling pathway activity — LUNG_NSCLC_LUAD

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