Positive regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, PLAU, and HIP1R, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of platelet-derived growth factor receptor signaling pathway activity versus F3 in STOMACH (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	F3 →	+4.198	+0.261	<.001	<.001	3	13
LUNG_NSCLC_LUAD	PLAU →	+2.677	+0.161	<.001	.002	3	7
BLOOD_Lymphoma	HIP1R →	+1.457	+0.508	.001	.001	3	7
CNS	HIP1 →	+1.177	+0.229	<.001	.009	3	6
UPPER_AERODIGESTIVE_TRACT	IL1B →	+3.437	+0.184	<.001	<.001	3	6
PANCREAS	AMPD3 →	+1.124	+0.171	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010641 vs F3 — STOMACH

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