Positive regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F3, SMURF2, and ZBTB7B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of platelet-derived growth factor receptor signaling pathway activity versus F3 in LIVER (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	F3 →	+3.593	+1.868	<.001	<.001	3	7
STOMACH	SMURF2 →	+3.675	+2.136	<.001	.007	3	4
LARGE_INTESTINE	ZBTB7B →	-1.138	-1.270	.003	.004	3	4
STOMACH	CLDN15 →	-2.345	-2.018	.007	.001	2	4
STOMACH	ARHGDIB →	+5.635	+2.136	.003	.007	3	3
LARGE_INTESTINE	MYO7B →	-3.063	-1.206	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010641 vs F3 — LIVER

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