Regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LOX, SFRP2, and VCAN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor signaling pathway activity versus LOX in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOX →	+0.900	+0.071	<.001	<.001	3	7
BRCA	SFRP2 →	+0.661	+0.046	<.001	<.001	3	6
OV	VCAN →	+0.844	+0.044	<.001	.001	3	6
COAD	COMP →	+0.995	+0.037	.002	.001	3	6
GBM	ISLR →	+0.612	+0.045	.001	.004	3	6
BRCA	FSTL1 →	+0.576	+0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010640 vs LOX — OV

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