Regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAU, CHI3L1, and S100A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor signaling pathway activity versus PLAU in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLAU →	+0.794	+0.519	.006	.002	3	4
GBM	CHI3L1 →	+1.701	+0.143	.006	.002	2	5
OV	S100A9 →	+2.045	+0.209	<.001	<.001	3	4
BRCA	CHST2 →	+0.776	+0.221	.005	.005	3	4
HNSC	RN7SKP11 →	+0.591	+0.120	.002	.003	3	4
CCRCC	ESRP2 →	-0.546	-0.148	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010640 vs PLAU — UCEC

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