Regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1B, NAP1L4, and XIAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor signaling pathway activity versus TUBA1B in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TUBA1B →	+0.807	+0.812	.006	.002	3	4
BLOOD_Lymphoma	NAP1L4 →	+0.523	+0.989	<.001	<.001	3	4
BONE	XIAP →	+1.082	+1.520	.005	<.001	3	4
BLOOD_Leukemia	COA1 →	+0.782	+1.273	<.001	<.001	3	4
BLOOD_Leukemia	CSRNP2 →	+0.972	+1.068	.005	.002	3	4
BLOOD_Leukemia	STKLD1 →	+0.554	+0.928	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010640 vs TUBA1B — BLOOD_Lymphoma

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