Negative regulation of mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Negative regulation of mitochondrial fusion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMG9_S32, FAM13A, and BNIP3_T137, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial fusion activity versus SMG9_S32 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMG9_S32 →	+0.219	+0.063	.002	.001	3	4
UCEC	FAM13A →	+0.354	+0.060	<.001	.002	3	4
PDAC	BNIP3_T137 →	+0.615	+0.069	<.001	<.001	3	4
LSCC	FAF1 →	+0.267	+0.072	<.001	<.001	3	4
OV	SRSF9_S193 →	-0.653	-0.059	.002	.004	3	3
GBM	CA9 →	+0.963	+0.061	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010637 vs SMG9_S32 — HNSC

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