Negative regulation of mitochondrial fusion

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAT1, DUSP3, and RBFA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial fusion activity versus VAT1 in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VAT1 →	+2.502	+0.323	.001	<.001	2	8
PANCREAS	DUSP3 →	+0.655	+0.195	<.001	.006	3	6
LUNG_NSCLC_LUSC	RBFA →	+1.387	+0.317	.008	.005	3	6
OESOPHAGUS	PTTG1IP →	+0.922	+0.194	<.001	<.001	3	5
OESOPHAGUS	STX2 →	+1.118	+0.216	.006	.001	3	5
SKIN	CDC16 →	+0.712	+0.125	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010637 vs VAT1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →