Negative regulation of mitochondrial fusion

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitochondrial fusion pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HUWE1, VAT1, and CAMKV, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial fusion activity versus HUWE1 in STOMACH (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HUWE1 →	+1.538	+0.275	<.001	.005	3	15
LUNG_NSCLC_LUSC	VAT1 →	+2.895	+0.381	<.001	<.001	3	15
URINARY_TRACT	CAMKV →	+1.575	+0.314	.001	.001	3	12
OVARY	TUBB4B →	+1.441	+0.130	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	RANBP3 →	+1.370	+0.180	.003	.002	3	12
OVARY	TXN →	+1.955	+0.157	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010637 vs HUWE1 — STOMACH

Explore this scatter interactively →