Regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN1, PDCD11, and CNNM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell migration activity versus TSPAN1 in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TSPAN1 →	+3.727	+0.320	.004	.002	3	7
URINARY_TRACT	PDCD11 →	-0.868	-0.363	.005	.004	3	7
URINARY_TRACT	CNNM2 →	-0.583	-0.306	<.001	.004	3	6
OVARY	SLC25A4 →	-1.292	-0.258	.002	.001	3	5
OVARY	LRP6 →	-1.016	-0.276	.001	.001	3	5
URINARY_TRACT	CHMP4B →	+0.723	+0.330	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010632 vs TSPAN1 — URINARY_TRACT

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