Negative regulation of Schwann cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of Schwann cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DBN1, APBB2, and CEP170, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Schwann cell proliferation activity versus DBN1 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DBN1 →	+0.415	+0.076	<.001	<.001	3	6
UCEC	APBB2 →	+0.359	+0.096	<.001	<.001	3	6
LUAD	CEP170 →	+0.253	+0.065	<.001	<.001	3	5
LSCC	FN1 →	+0.532	+0.067	.002	<.001	2	6
UCEC	MMP2 →	+0.485	+0.069	.001	.001	3	5
CCRCC	RAB23 →	+0.404	+0.075	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010626 vs DBN1 — LSCC

Explore this scatter interactively →