Negative regulation of Schwann cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of Schwann cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFFO1, ZNF831, and FAM78A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Schwann cell proliferation activity versus IFFO1 in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFFO1 →	-0.371	-0.233	.002	.005	3	4
HNSC	ZNF831 →	-0.692	-0.283	<.001	.006	3	4
HNSC	FAM78A →	-0.435	-0.259	.005	.001	3	4
UCEC	RASGRP2 →	-0.593	-0.640	<.001	.003	3	4
UCEC	IL12RB1 →	-0.691	-0.776	<.001	.001	3	4
HNSC	CD247 →	-0.804	-0.258	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010626 vs IFFO1 — HNSC

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