Negative regulation of Schwann cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of Schwann cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLFN13, SLC16A4, and HID1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Schwann cell proliferation activity versus SLFN13 in SKIN (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLFN13 →	+1.667	+1.630	<.001	.009	3	2
LUNG_SCLC	SLC16A4 →	+0.466	+1.839	.006	.001	3	2
SKIN	HID1 →	-0.181	-1.115	.002	.004	3	1
SKIN	RASGRP4 →	-0.032	-1.045	.005	.009	3	1
LUNG_SCLC	FAM83D →	-0.723	-1.839	.009	.001	3	1
LUNG_SCLC	UQCRC1 →	+0.730	+1.839	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010626 vs SLFN13 — SKIN

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